Moreover, the expression level of key EMT-related proteins such as N-Cad, MMP9, Vimentin, Slug and Snail were correspondingly decreased (Fig. 4i, j), which indicated us that the up-regulated CDCA3 could participate in the EMT process of bladder urothelial carcinoma. This evidence concerns the gene CDCA3 and bladder transitional cell carcinoma.