Pérez-Pea et al. [13] found five cycle regulating genes associated with worse RFS and OS in Luminal type A breast cancer, including CDCA3. CDCA3 was also reported to regulate E2F1 [15] or activate the NF-κB signaling pathway by interacting with TRAF2 [16] in colorectal cancer. This evidence concerns the gene CDCA3 and breast carcinoma.