Moreover, as silencing the expression of CDCA3 could significantly inhibit the proliferation ability of bladder urothelial carcinoma cells both in vitro and in vivo (Figs. 3 and 6), it is reasonable to define that the inhibitory effect of silencing CDCA3 on cell growth is mainly mediated by arresting bladder urothelial carcinoma cells in G1 phase. The gene discussed is CDCA3; the disease is bladder transitional cell carcinoma.