CCND1 and neoplasm: Besides, the tumor-suppressive effects of Lactobacillus casei were associated to 60 fold higher mRNA expression of TRAIL (Tumor necrosis factor-related apoptosis-inducing ligand), as an effective gene in the activation of extrinsic apoptosis signaling pathway, and 10 fold lower mRNA expression of cyclin D1 (a protein required for progression through the G1 phase of the cell cycle), and BIRC5 (Baculoviral IAP repeat-containing 5), that encode the anti-apoptotic protein Survivin [27].