IL-1β-induced synovitis resulted in moderate, transient increases in heart rate (HR) and rectal temperature (T) (synovitis peak HR: 52 ± 2 beats per minute at 12 h, p = 0.0001; synovitis peak T: 101.1 ± 0.2 °F at 12 h, p = 0.0001), while lavage resulted in a slight increase in rectal temperature at 12 h (lavage peak T: 99.6 ± 0.1 °F, p = 0.001) and no increases in HR (Supplemental Data 1A-D). The gene discussed is IL1B; the disease is synovitis.