The results indicated that Fib status (P <  0.001), tumour size (P = 0.002), lymph node involvement (P <  0.001), molecular subtype (HR(−)HER2(+) vs HR (+) HER2(−), P = 0.003; HR(−)HER2(−) vs HR (+)HER2(−), P = 0.001) and Ki67 index (P = 0.001) were the potential factors affecting the pCR to NAC. This evidence concerns the gene MKI67 and neoplasm.