When stratified by tumour size (>5 cm or ≤ 5 cm), as shown in Fig. 3, patients with low Fib levels exhibited better 3-year RFS compared with patients with high Fib levels in the tumour size>5 cm group (77.5% vs 58.4%, log-rank, P = 0.0168). This evidence concerns the gene FBL and neoplasm.