Among the top deregulated pathways validated with human data, we found as expected AML associated signaling such as the RAF/MEK/ERK and PI3K/AKT cascades; interestingly, we observed upregulation of proteins involved in the RET signaling (Epiregulin, Gfra-1, Shp-2), recently highlighted as a mediator of normal HSC maintenance and expansion (Grey et al., 2020). The gene discussed is PTPN11; the disease is acute myeloid leukemia.