This is consistent with previous findings that optimal galectin-3 induction requires TCR signaling (Joo et al., 2001), and in the tumor microenvironment, galectin-3 is differentially expressed on the surface of tumor-antigen activated CD8+ T cells, but is absent in resting T cells (Joo et al., 2001; Kouo et al., 2015). This evidence concerns the gene CD8A and neoplasm.