Although the ranking order may vary, the majority of the top-ranked TEff/EM regulons such as Rora (Best et al., 2013), Fosl2 (Ciofani et al., 2012), Creb3 (Chan et al., 2011), Maf (Ciofani et al., 2012), Prdm1 (Kallies et al., 2009), Nfil3 (Kashiwada et al., 2011), and Nfkb1 (Best et al., 2013) were also identified as top-ranked regulons for active TRMs in the tumor and distant mammary mucosa. This evidence concerns the gene FOSL2 and neoplasm.