We found RIPK1 kinase activation in microglia and astrocytes induced expression of various genes whose deficiency is protective in EAE or whose expression is increased in MS patients, including Bhlhe40, Mir155hg, Rgs1, and Lcn2 (Al Nimer et al., 2016; Lee and Bou Dagher, 2016; Lin et al., 2014; Murugaiyan et al., 2011; O’Connell et al., 2010). Here, LCN2 is linked to myeloid sarcoma.