Genes involved in lipid metabolism or the transcription factor Bhlhe40 and microRNA mir155hg, both of which have been implicated as detrimental in a mouse model of MS (Lin et al., 2014; Murugaiyan et al., 2011; O’Connell et al., 2010), were upregulated in a RIPK1-kinase-dependent manner (Figure S3E). Here, BHLHE40 is linked to myeloid sarcoma.