Consistent with the translational relevance of microglial RIPK1 kinase activation, the core RIPK1-kinase-dependent transcriptional signature contained many pro-inflammatory cytokines and chemokines, such as Ccl3, Ccl4, Il1β, Il6, and Cxcl1, elevated in MS patients and implicated in MS pathogenesis (Göbel et al., 2018; Khaibullin et al., 2017; Soleimani et al., 2019; Stampanoni Bassi et al., 2018). This evidence concerns the gene IL1B and myeloid sarcoma.