SAMHD1 and HIV-1 infection: We targeted the host viral restriction factor SAMHD1, which blocks lentiviral infection (including HIV-1 infection) by depleting intracellular pools of deoxynucleoside triphosphates (dNTPs) needed for reverse transcription (St Gelais and Wu, 2011; Hrecka et al., 2011; Laguette et al., 2011; Sunseri et al., 2011).