We found ASS1 upregulation in primary AML blasts, and ASS1 overexpression has been reported in a number of other cancers (Bateman et al., 2017; Henriet et al., 2017; Rho et al., 2008; Shan et al., 2015a, 2015b; Szlosarek et al., 2007; Tsai et al., 2018), suggesting clinical relevance. This evidence concerns the gene ASS1 and acute myeloid leukemia.