At an optimal cutpoint of 244 μg/gcreatinine, NGAL distinguished ATN (344 [132, 1,429] μg/g creatinine)from prerenal AKI (45 [0, 154] μg/g) or HRS (110 [50, 393] μg/g;P < 0.001), with a C statistic of 0.762 (95%confidence interval 0.682, 0.842). This evidence concerns the gene LCN2 and acute kidney injury.