Combined, these data demonstrate that high titers of anti-spike IgG from serum of severely ill COVID-19 patients induce a strong pro-inflammatory response by otherwise immunosuppressive human M2 macrophages, which is characterized by production of classical cytokine storm mediators such as IL-1β, IL-6, IL-8, and TNF. The gene discussed is CXCL8; the disease is COVID-19.