Anticancer immunity consists of 3 main phenotypes: immune-desert, immune-excluded, and inflamed phenotypes17, which are subject to several key steps, including the release of cancer-cell antigens, antigen presentation, CD8+ T cell priming and activation, trafficking and infiltration of CD8+ T cells into tumors, and ultimately recognizing and killing cancer cells using CD8+ T cells. The gene discussed is CD8A; the disease is cancer.