PMEL and cancer: Typical classes of TAAs include overexpressed antigens in cancer cells16,34, such as human epidermal growth factor receptor 2 (HER2), mucin-1 protein (MUC1), survivin and human telomerase reverse transcriptase (hTERT) plus cancer/germline antigens in germline cells, such as New York esophageal cancer antigen-1 (NY-ESO-1), the melanoma-associated antigen (MAGE) family and X antigen family member-1b (XAGE-1b), lineage-specific antigens in specific cells such as tyrosinase, glycoprotein 100 (gp100), melanoma antigen recognized by T cell-1 (MART-1), and prostate-specific antigen (PSA).