MAPT and Mental deterioration: To validate whether Rbbp7 is dysregulated in mouse models of AD, we first extracted the hippocampus of 12-month-old female 3xTg-AD (n = 4) and NonTg (n = 5) mice, which have well-documented cognitive decline and marked build-up of Aβ deposits and pathological tau at this age, and measured Rbbp7 levels via immunoblot [9].