Another example is given by the G4-forming sequence found in the promoter region of the vascular endothelial growth factor (VEGF) which, when hybridized to its C-rich counterpart, causes the downregulation of the growth factor, finding potential application in the treatment of cancer forms in which VEGF is upregulated, such as non-small cell lung carcinoma (145). The gene discussed is VEGFA; the disease is cancer.