Integrating co-mapping SNPs between protein abundance and phenotypic traits (GWAS Catalog, all associations file from 2020-10-07, v1.0.2, P < 1e–11) (Figure 3B) highlights several well characterised intragenic co-mapping SNPs associated to CFH and CFB, and age-related macular degeneration (37) including several other less characterised phenotypic associations such as potential links between CFB, CFH and obesity. The gene discussed is CFH; the disease is obesity due to melanocortin 4 receptor deficiency.