These results suggest that nhr-49/PPARA may play other roles in host defense against infection, aside from the induction of fmo-2/FMO5 (which is not induced by P. aeruginosa [Figure 3—figure supplement 1 and Irazoqui et al., 2008, Irazoqui et al., 2010a]). Here, FMO2 is linked to infection.