HTR5A and Anxiety: These included the nucleus accumbens (NAc) based on 5HT's role on social reward in this region,25 the BNST for its role in adaptive anxiety,66 and additional hypothalamic and cortical regions of interest, including the ACC, lateral parietal association (PtA), orbitofrontal cortex (OFC) and the peduncular part of the lateral hypothalamus (PLH) which is where the medial forebrain bundle is found, representing a major ascending pathway for nearly all 5HT axons (Figure 4(B)).67