In rheumatoid arthritis, anautoimmune disease, atrial remodeling occurs which can lead to the appearance ofatrial fibrillation, but in collagen-induced arthritis rats, resveratrol was able toreduce the duration of atrial fibrillation episodes, in part by decreasing theproduction of IL-6, TNF-a and lower atrial remodeling45. The gene discussed is TNF; the disease is atrial fibrillation.