IL1RAP and chronic myelogenous leukemia, BCR-ABL1 positive: However, CML stem cells, which are independent of the activity of BCR-ABL14,5, express the markers CD266, interleukin-1 receptor accessory protein (IL1RAP)7, and CD938, and are the cause of disease relapse and progression to blast crisis (BC) (Table 1), are not eradicated by TKIs5,9,10.