RUNX1 and breast cancer: Most common chromosomal abnormalities reported in BC involve chromosomes 17, 8, or 19 or the Philadelphia (Ph) chromosome, which harbors the BCR-ABL1 fusion itself, while, molecularly, the MDS1 and EVI1 complex locus (MECOM) gene and tumor suppressors like RB1, TP53, and CDKN2A are frequently affected29.