However, CML stem cells, which are independent of the activity of BCR-ABL14,5, express the markers CD266, interleukin-1 receptor accessory protein (IL1RAP)7, and CD938, and are the cause of disease relapse and progression to blast crisis (BC) (Table 1), are not eradicated by TKIs5,9,10. Here, BCR is linked to chronic myelogenous leukemia, BCR-ABL1 positive.