LGALS3 and hydrops fetalis: When Gal-3 was measured at the time of MI, elevated levels were associated with an increased risk of subsequent HF (hazard ratio [HR] 1.4, 95% confidence interval [CI] 1.0–2.0 for tertile 2 compared with tertile 1 and HR 2.3, 95% CI 1.6–3.2 for tertile 3 compared with tertile 1) and death (2.4-fold increased risk for tertile 3 compared with tertile 1)20.