Changes in Gal-3 between assessments were associated with incident HF (HR 1.39, 95% CI 1.13–1.71), CVD (HR 1.29, 95% CI 1.11–1.51), and all-cause mortality (HR 1.30, 95% CI 1.17–1.46)46. Here, LGALS3 is linked to hydrops fetalis.