NPPB and hydrops fetalis: Indeed, a recent analysis of GUIDE-IT showed that patients able to achieve a reduction in NT-proBNP to less than 1000 pg/mL, regardless of randomization arm, had a substantially lower risk of cardiovascular or HF hospitalization (HR 0.26, 95% CI 0.15–0.46) and all-cause mortality (HR 0.34, 95% CI 0.15–0.77) and improved quality-of-life scores25.