Of note, female S6K1−/− mice are long‐lived and have a reduced incidence of age‐related diseases.(20) Concordance in the phenotypes of calorie‐restricted mice and Rptorob−/− mice (i.e., hypoleptinemia, hypoinsulinemia, high corticosterone, and an increase in ketone bodies) suggests that loss of mTORC1 function in OBs mimics a starvation response. This evidence concerns the gene RPS6KB1 and Hypoinsulinemia.