These observations are in line with findings in adult patients with T1DM (128 men and premenopausal women mean age, 43.4 ± 8.8 years) with a long duration of disease (22.4 ± 9.5 years) that exhibited higher levels of serum sclerostin, irrespective of sex.(20) The elevated sclerostin levels could partially explain the blunted bone formation seen in those subjects with T1DM. The gene discussed is SOST; the disease is type 1 diabetes mellitus.