INS and Hyperglycemia: The autoimmune‐prone nonobese diabetic (NOD) mouse model recapitulates many aspects of human T1DM.(27, 28) NOD mice show signs of insulitis at approximately 4 to 5 weeks (puberty) and, similar to humans, develop full T1DM at approximately 12 weeks of age (young adult).(29) Unlike humans, diabetic NOD (D‐NOD) mice exhibit mild ketoacidosis, allowing them to survive for several weeks after the onset of hyperglycemia without supportive insulin treatment.