HMGA2 and cancer: (50, 72) Importantly, another ncRNA gene, LINC02454, which exhibits an HMGA2‐like expression pattern (Supplementary Fig. S10), is 9 kb downstream of the three Tier‐1 SNPs in an ostb‐associated super‐enhancer far from HMGA2. LINC02454 was previously referenced only for its dysregulation in cancer cells.(73) We propose that one or several of the HMGA2‐far upstream Tier‐1 SNPs help control expression of LINC02454, which, in turn, helps regulate transcription of HMGA2 in MSC.