NPR3 (NPRC) is involved not only in linear bone growth, bone turnover, and endochondral ossification,(29, 61, 62, 63) but also in cardiovascular homeostasis, and renal cancer metastasis.(29, 63) Its Tier‐1 SNPs (rs1173771 and rs7733331), which are in almost perfect LD, are upstream of another novel TSS observed preferentially in ostb and chond (Fig. 3C and Supplementary Fig. S8). The gene discussed is NPR3; the disease is renal carcinoma.