LGR4, which had one associated Tier‐1 SNP (Fig. 4), encodes a bone‐related Wnt signaling receptor(30, 56) and had been catalogued as one of many genes with an eBMD‐associated missense SNP (rs34804482) predicted to have a deleterious effect on protein structure.(6) Moreover, Styrkarsdottir et al.(57) found a rare nonsense mutation in the gene that is associated with low BMD, osteoporotic fractures in elderly individuals, electrolyte imbalance, and several types of cancer. Here, LGR4 is linked to Abnormality of metabolism/homeostasis.