LGR4 and cancer: LGR4, which had one associated Tier‐1 SNP (Fig. 4), encodes a bone‐related Wnt signaling receptor(30, 56) and had been catalogued as one of many genes with an eBMD‐associated missense SNP (rs34804482) predicted to have a deleterious effect on protein structure.(6) Moreover, Styrkarsdottir et al.(57) found a rare nonsense mutation in the gene that is associated with low BMD, osteoporotic fractures in elderly individuals, electrolyte imbalance, and several types of cancer.