In a recent study, we used epigenetics to prioritize best‐candidate causal regulatory variants for BMD GWAS SNPs and obesity GWAS SNPs at a single gene, TBX15, which encodes a limb development‐associated transcription factor (TF).(18) In the present study, we take the unusual approach of looking genome‐wide not only for SNPs overlaying enhancer or promoter chromatin in ostb but also for such SNPs that displayed these types of regulatory chromatin preferentially in ostb relative to many types of cell cultures not directly related to bone. Here, SLC51B is linked to obesity due to melanocortin 4 receptor deficiency.