Epigenetic profiles of osteoclasts are not available but the finding of negligible levels of expression of Lgr4 (and the mouse homologs of the other Tier‐1 associated genes) in cultured mouse osteoclasts and substantial levels in mouse ostb (Supplementary Fig. S6) suggests that the LGR4 Tier‐1 SNP's regulatory role in osteoporosis risk is through ostb and possibly osteocytes. The gene discussed is LGR4; the disease is osteoporosis.