Our findings further revealed that the elevated plasma TMAO and blood indictors reflecting the atherosclerosis such as Apo-A1, Apo-B, and HDL-C had good diagnostic performance for those vulnerably suffered LAA stroke, which added to the existing evidence presenting that TMAO level may regard as a useful and potential prognostic biological indictor in LAA stroke, even beyond the currently clinic routine check. This evidence concerns the gene APOA1 and atherosclerosis.