AFP and neoplasm: Whereas the sensitivities of CEA+CA19-9 and CEA+AFP+CA19-9 were 3.6% and 10%, respectively, for AA and SP, those of mSDC2 were 25% for both AA and SP, and those of mSEPT9+mSDC2 were 39.3% and 30.0% for AA and SP, respectively, which were 10.9- and 3-fold higher than those of the two tumor marker combinations.