NDRG4 and colorectal carcinoma: And methylation of various genes has been proposed as biomarkers for CRC [33] including SEPT9 [34, 35], SDC2 [12], secreted frizzled related protein 2 (SFRP2) [36, 37], N-myc downstream regulated gene family member 4 (NDRG4) [37, 38], vimentin (VIM) [37, 39], and bone morphogenetic protein 3 (BMP3) [38] genes.