IKZF1 and liver cancer: It has been reported that expression of LHX6 gene was significantly down‐regulated by DNA methylation and plays a tumor suppressing role during hepatocarcinogenesis, suggesting that LHX6 can be considered as a potential target gene and a biomarker for liver cancer treatment.[18] In another example, the PWM M23 of HBV could match the motif of DNA‐binding protein Ikaros (IKZF1).