ZNF16 is a tumor associated gene and its alteration might promote malignancy of tongue squamous cell carcinoma (TSCC) cells.[25] We also found that the PWM M30 of EBV matched the motif of the transcriptional activator, namely, transcription factor COE1 (EBF1) (Figure 5F). The gene discussed is EBF1; the disease is tongue squamous cell carcinoma.