The Z3 complex, represented by ZMYND8, has been shown to interact with members in the KDM5 subfamily, such as KDM5C and KDM5D, to activate or repress gene expression.[20, 35, 45] Similar as KDM5C, the expression of ZMYND8 was found to be significantly higher in clinical breast tumor samples than normal breast tissues (Figure 5B). This evidence concerns the gene KDM5D and breast neoplasm.