In consistent with its oncogenic nature, ZMYND8 expression is upregulated in both prostate cancer xenografts in zebrafish and prostate cancer samples from patients.[38] In breast cancer, ZMYND8, together with KDM5C, functions as a tumor suppressor by preventing hyperactivation of enhancers associated with oncogenes, such as S100A family genes, and suppresses anchorage‐independent growth, migration, and invasion abilities in vitro, as well as enhances tumor growth in a mouse xenograft model.[20] In contrast, Chen et al. Here, S100A1 is linked to neoplasm.