In clear cell renal cell carcinoma, inactivating mutations were found in KDM5C, which led to the aberrant activation of heterochromatin non‐coding RNAs that subsequently triggered genomic instability.[17] In breast cancers, KDM5C was found to be significantly upregulated compared to normal breast tissues and positively correlated with metastasis. The gene discussed is KDM5C; the disease is clear cell renal carcinoma.