KDM5C and breast neoplasm: The Z3 complex, represented by ZMYND8, has been shown to interact with members in the KDM5 subfamily, such as KDM5C and KDM5D, to activate or repress gene expression.[20, 35, 45] Similar as KDM5C, the expression of ZMYND8 was found to be significantly higher in clinical breast tumor samples than normal breast tissues (Figure 5B).