KDM5C binds to tri‐methylated lysine 9 on histone H3 (H3K9me3) via its N‐terminal PHD finger, which is required for it to efficiently demethylate H3K4me2/3 and repress gene transcription.[10] KDM5C has been shown to play an essential role in neurogenesis, DNA damage response, and cancer development, among others. This evidence concerns the gene KDM5C and cancer.