developed an ApoE peptide (LRKLRKRLL)2C‐decorated chimeric polymersomes (CP) (ApoE‐CP) for targeting delivery of therapeutic protein to glioma (Figure 10A).[140] ApoE peptide, a tandem dimer sequence of the receptor‐binding domain of ApoE, was reported to possess high affinity to multiple LDLR members, such as LDLR, LRP‐1, and LRP‐2 without interfering with endogenous ApoE. This evidence concerns the gene APOE and central nervous system cancer.