synthesized a circular bifunctional aptamer (Tau‐TfR Aptamer) possessing the dual‐targeting ability for better taupathy therapy (Figure 6B).[153] The circular aptamer consists of TfR aptamer that targets TfR on the BBB and tau protein aptamer that selectively targets tau in diseased neuron, thus inhibiting tau phosphorylation and other tauopathy‐related pathological events in the brain. Here, MAPT is linked to tauopathy.