A cholesterol‐rich diet can aggravate atherosclerosis in apoE−/− mice.[28] To evaluate the efficacy of 3‐HB treatment for atherogenesis, apoE−/− mice were fed a cholesterol‐rich diet and concomitantly administrated with 3‐HB, NA (positive control), and 0.9% saline (vehicle control) intragastrically for 9 weeks, respectively. Here, APOE is linked to atherosclerosis.