AKT1 and cancer: In the KEGG signal pathway, the up-regulation of DEGs mostly involved in the PI3K-Akt signaling pathway, pathways in cancer, focal adhesion, and HIF-1 signaling pathway (Fig. 3D); while the down-regulation of DEGs mainly involved in the metabolic pathway, Biosynthesis of antibiotics, Carbon metabolism, and Aldosterone-regulated sodium reabsorption (Fig. 3H).