Furthermore, autophagy regulators BECN1 and PIK3C3 interact with UVRAG (UV radiation resistance-associated), and UVRAG ubiquitination at its K517 and K559 residues and promoted autophagosome maturation as well as lysosomal degradation of epidermal growth factor receptor (EGFR), leading to the inhibition of HCC cell growth [107]. The gene discussed is BECN1; the disease is hepatocellular carcinoma.