In the last decade, numerous studies have shown that the auto infiltration or polarization pathway of tumor-associated macrophages (TAMs) has the potential to become the new targets of malignant tumor treatment 25.The results of this study indicate that CFP expression is closely correlated to TAMs while being less correlated to M1 comparing M2 (Supplementary Table 1, Table 2) and M2 phenotype of TAMs generally considered more resemble primary tumors in terms of function 26. The gene discussed is CFP; the disease is cancer.