As shown in Figure 6B-D, we identified that decreased expression level of PLK1 in glioma cells obviously inhibited cell proliferation, migration, and invasion, while co-transfection of PLK1 siRNA and miR-1224-3p inhibitor in glioma cells respectively reversed the inhibition influence of si-PLK1 on glioma cells. Here, PLK1 is linked to central nervous system cancer.