PLK1 and central nervous system cancer: Then, we analyzed the correlation between miR-1224-3p and PLK1 in glioma tissues and a negative relationship between these two molecules was observed in low grade glioma tissues (R2=0.29, p<0.001) (Figure 5D) and high grade glioma tissues (R2=0.33, p<0.001) (Figure 5E).