Besides, correlation analysis verified that circ-ZNF609 expression was negatively interrelated to miR-1224-3p expression in low grade glioma tissues (R2=0.36, p<0.001) (Figure 3G) and high grade glioma tissues (R2=0.32, p<0.001) (Figure 3H). Here, ZNF609 is linked to central nervous system cancer.