BGN, NOX4, SPARC, HEYL, SPP1, CTHRC1, SFRP4, FBXO32, KIF4A, MMP9, TIMP1 were related to the proliferation, invasion, prognosis, and recurrence of GC in different level and validated in many kind of tumors 25-37. This evidence concerns the gene SPP1 and gastric cancer.