Xing et al. found that ZNF692 promoted colon adenocarcinoma cell growth and metastasis by activating the PI3K/AKT pathway 30, and Qin et al. also found that ZNF281 regulates cell proliferation, migration and invasion in colorectal cancer through Wnt/β-Catenin signaling 31. The gene discussed is AKT1; the disease is colon adenocarcinoma.