CDC37 and breast cancer: CDC37 triggers breast cancer cell proliferation by regulating CDK2 activation and CDC37 depletion could reduce the activity of the mitogen-activated protein kinase 1 (Erk), AKT Serine/Threonine Kinase 1 (Akt), Mechanistic Target of Rapamycin Kinase (mTOR), resulting in prostate tumor cell growth suppression 12, 13.