VIM and bipolar disorder: Our network analysis also identified a cluster of proteins indirectly associated with vimentin and chromogranin A (both upregulated in reactive astrocytes) [45, 46], both forming part of the defined schizophrenia and bipolar disorder networks, respectively (Supplementary Table S4), as well as significantly downregulated proteins that form part of GABA receptor signaling and glutamate degradation, associating with both schizophrenia and bipolar disorder spectrum disorder (Supplementary Table S4).