IL17A and infection: Since the anti-Ly6G antibody was particularly effective at depleting Siglec-F+ neutrophils and since these cells are selectively reduced in Il17A−/− mice, which have defective clearance of bacteria from the nasal mucosa, our findings point to a protective role for IL-17-induced Siglec-F+ neutrophils in protective immunity against infection of the nose with B. pertussis, but do not rule out a role for Siglec-F− neutrophils.