In addition, the expression of SOCS3 in donor T cells is reported to negatively regulate GVHD pathophysiology [36], supporting our observation of upregulated SOCS3 expression and amelioration of clinical signs of GVHD by CD45RA/CD276 depletion in DR4-mismatched setting. The gene discussed is TNFRSF10A; the disease is graft versus host disease.