Since our in vitro data (Fig. 2a) and peripheral blood analysis in NSG-Ab°DR4 mice (Fig. 4b) demonstrated increased TH17 compartment after CD45RA/CD276 depletion, to further clarify the contribution of pathogenic TH17 cells in this mouse model, we analyzed the expression of RORC, GATA3, T-bet, Foxp3, and SOCS3 in GVHD target organ-infiltrating T cells. Here, CD276 is linked to graft versus host disease.