PPARD and type 2 diabetes mellitus: The PPARD rs1053049 (T>C; 3′-untranslated region of exon 9) TT genotype demonstrated reduced PPARD gene expression levels41, higher levels of low-density lipoprotein cholesterol and increased risk of type 2 diabetes mellitus47, increased insulin sensitivity and decreased body mass with sports training or lifestyle intervention26,48,49.