In colorectal cancer pathogenesis, lncRNAs are implicated in a variety of signaling pathways including the Wnt/-catenin signaling pathway, epidermal growth factor receptor (EGFR)/insulin-like growth factor type I receptor (IGF-IR) signaling pathway, KRAS and phosphatidylinositol-3-kinase (PI3K) pathways, transforming growth factor-beta (TGF-) signaling pathway, p53 signaling pathway, and the epithelial-mesenchymal transition (EMT) pathway31. This evidence concerns the gene TP53 and colorectal cancer.