IDH1 and acute myeloid leukemia: In multivariate analysis, IDH1 mutations had an independent prognostic impact on increased risk of death in both the HR NK-AML (p = 0.04) and NPM1−/FLT3-ITD− (p = 0.026 with HR:2.23, 95% CI 1.1–4.54) subgroups after censoring at alloHSCT (Table 2).