VPS35 vaccination inhibited tumor growth by 40% (p = 0.0008, from 269.5 ± 30.9 mm3 to 157.4 ± 17.8 mm3), vaccination with SERBP1 inhibited tumor growth by 60% (p < 0.0001, from 430.8 ± 42.8 mm3 to 175.8 ± 8.9 mm3), vaccination with KRT8 inhibited tumor growth by 67% (p < 0.0001, from 520.3 ± 44.5 mm3 to 173.8 ± 16.3 mm3), and vaccination with PDIA6 inhibited tumor growth by 62% (p < 0.0001, from 520.3 ± 44.5 mm3 to 198.4 ± 22.3 mm3) as compared to PBS controls (Fig. 3 and Supplementary Fig. 4). The gene discussed is PDIA6; the disease is neoplasm.