Although the precise interaction of the SARS-CoV-2 N protein with MASP-2 remains to be elucidated, our work defined the region on the SARS-CoV-2 N protein recognized by the mAb nCoV396 that plays an important role in complement hyperactivation and indicates that human mAbs from convalescents could be a promising potential therapeutic candidate for the treatment of COVID-19. Here, MASP2 is linked to COVID-19.