The increased expression of ZBP1 and RIPK3 also happens in mouse melanoma B16, mouse lung cancer LLC, human breast cancer MCF-7 and MDA-MB-231 tumors as their expression levels are significantly higher in the cells from tumors compared to that in the cultured parental cells (Fig. 2d, e and Supplementary Fig. 2e, f). This evidence concerns the gene ZBP1 and breast cancer.