ZBP1 and neoplasm: In this current study, we found that RIPK1 is not required for tumor necroptosis during tumor development in MVT1 breast cancer model and may have an inhibitory effect on the induction of tumor necroptosis, this finding is consistent with previous reports that the necroptosis-inducing activity of ZBP1 is hindered by RIPK1 during normal embryonic development43.