CASP3 and neoplasm: In addition, as interferons (IFNs) are known to induce tumor cell death and ZBP1 expression31, we also checked if IFNs could induce necroptosis in these tumor cells and found that IFNs do not induce MLKL phosphorylation, but some Casp-3 cleavage (Supplementary Fig. 4f, g).