Using AgRP-Cre GFP-reporter mice to visualize AgRP neurons, we found that T1D-induced c-Fos expression was partly colocalized with AgRP neurons but also found in a large number of non-AgRP neurons (Fig. 1l, bottom panels), whereas a negligible number of c-Fos neurons was observed in control non-T1D mice (Fig. 1l, top panels). Here, FOS is linked to type 1 diabetes mellitus.