We report, at a very high level of resolution, the overall breadth and kinetics of 18 key immune parameters: the antiviral/inflammatory cytokines and chemokines, hemagglutinin (HA)-directed antibodies, HA-probe-specific B cells, antibody-secreting cells (ASCs), circulatory CD4+ T follicular helper (cTfh) cells, influenza peptide/MHC-specific CD8+ and CD4+ T cells, IFN-γ-producing CD8+ T cells, CD4+ T cells, natural killer (NK) cells, mucosal-associated invariant T (MAIT) and γδ T cells, and granzymes A, B, K, M and perforin expression in CD8+, CD4+, NK and MAIT cells. The gene discussed is CD8A; the disease is influenza.