However, overexpression of PARP9 in PARP9 and MAVS DKO BMDC did not affect the IL-6 production in response to intracellular poly I:C or viral dsRNA Reo1198 (Supplementary Fig. S11d) or reovirus infection (Supplementary Fig. S11e). This evidence concerns the gene PARP9 and Reoviridae infectious disease.