Knockdown of either PARP9 or MAVS reduced the production of IFN-α (Fig. 1j) and IFN-β (Fig. 1k) in human MDDC in response to LPIC or reovirus infection, but not to dsDNA HSV-60 or cGAMP treatment (Fig. 1j and k). The gene discussed is MAVS; the disease is Reoviridae infectious disease.