Knockdown of AKT3, but not AKT1 or AKT2, substantially reduced the enhanced expression of IFN-β at mRNA level in BMDC infected by VSV or reovirus (Fig. 7c), suggesting that AKT3 is the possible downstream target of PI3K activation after VSV or reovirus infection. Here, AKT1 is linked to Reoviridae infectious disease.