Compared to PARP9 and MAVS DKO BMDC, MAVS KO produced significantly more IFN-α (Figs. 5c and 5e) and IFN-β (Fig. 5d and f) in response to stimulation with intracellular poly (I:C) (Fig. 5c and d) or reovirus infection (Fig. 5e and f). The gene discussed is PARP9; the disease is Reoviridae infectious disease.