mTOR signaling is also strongly associated with various brain disorders, including brain tumors, epilepsy, neurodegenerative disorders (e.g., Alzheimer’s and Parkinson’s diseases), neurocutaneous diseases (e.g., tuberous sclerosis complex and neurofibromatosis), intellectual disability, autism spectrum disorders (ASD), depression, and diseases of abuse (e.g., alcoholism)5–12. Here, MTOR is linked to Intellectual disability.