In addition, tumor-infiltrating Treg cells showed distinct expression of chemokines and chemokine receptors, e.g., IL-8 (CXCL8), CX3CR1, CXCR7, and CCR10 (Supplementary Fig. 6c), some of which have been proposed as a prognostic marker and/or therapeutic target in cancer56. The gene discussed is ACKR3; the disease is neoplasm.